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ManuScript Details
Paper Id: IJCIRAS1738
Title: TASTE MASKED ORALLY DISINTEGRATING GRANULES OF IBUPROFEN BY MELT GRANULATION TECHNIQUE: A COMPARATIVE STUDY
Published in: International Journal Of Creative and Innovative Research In All Studies
Publisher: IJCIRAS
ISSN: 2581-5334
Volume / Issue: Volume 3 Issue 11
Pages: 9
Published On: 5/2/2021 1:18:19 AM      (MM/dd/yyyy)
Main Author Details
Name: Dr. Mrs. Pradnya Palekar - Shanbhag
Institute: Oriental College of Pharmacy
Co - Author Details
Author Name Author Institute
Miss. Drushti Rane Oriental College of Pharmac
Abstract
Research Area: Pharmacy, Pharmacology & theraputics
KeyWord: orally disintegrating granules; ibuprofen; melt granulation; taste masking; glyceryl monostearate; glyceryl behenate; stearic acid; Eudragit EPO
Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) used for treatment of pain and fever relief are generally bitter in taste. Ibuprofen is an NSAID, belonging to the class of propionic acid derivatives. Conventional solid dosage forms such as tablets and capsules with bitter taste are not palatable; also geriatric and pediatric patient population usually suffer from swallowing difficulties because of the size and weight of these dosage forms. The objective of the study was to formulate taste masked orally disintegrating granules of Ibuprofen with polymer and low melting waxes using melt granulation technique. Formulations using stearic acid with Eudragit EPO and combination of different types of waxes such as glyceryl monostearate, glyceryl behenate with stearic acid were prepared for effective taste masking of the drug. The ratio of Ibuprofen and stearic acid 1:1 was able to give optimal result in masking the bitter taste and obtained desired in vitro release. The granules were found to have excellent flow properties. The in vitro release of the granules was compared with marketed tablet. Optimized formulations of granules showed 90% release of Ibuprofen in 60 mins which is comparable to that of the marketed tablet.
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IEEE
Dr. Mrs. Pradnya Palekar - Shanbhag, Miss. Drushti Rane, "Taste masked orally disintegrating granules of Ibuprofen by melt granulation technique: A comparative study", International Journal Of Creative and Innovative Research In All Studies, vol. 3, no. 11, pp. 42-50, 2021.
MLA Dr. Mrs. Pradnya Palekar - Shanbhag, Miss. Drushti Rane "Taste masked orally disintegrating granules of Ibuprofen by melt granulation technique: A comparative study." International Journal Of Creative and Innovative Research In All Studies, vol 3, no. 11, 2021, pp. 42-50.
APA Dr. Mrs. Pradnya Palekar - Shanbhag, Miss. Drushti Rane (2021). Taste masked orally disintegrating granules of Ibuprofen by melt granulation technique: A comparative study. International Journal Of Creative and Innovative Research In All Studies, 3(11), 42-50.
Taste masked orally disintegrating granules of Ibuprofen by melt granulation technique: A comparative study
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