ManuScript Details
|
Paper Id:
|
IJCIRAS1273
|
|
Title:
|
LYOPHILIZATION TECHNOLOGY FOR THE DESIGN, DEVELOPMENT, OPTIMIZATION AND EVALUATION OF AN ANTICANCER DRUG: DACARBAZINE
|
| Published in: |
International Journal Of Creative and Innovative Research In All Studies |
| Publisher: |
IJCIRAS |
| ISSN: |
2581-5334 |
| Volume / Issue: |
Volume 2 Issue 1 |
| Pages: |
13
|
| Published On: |
6/29/2019 4:47:06 AM (MM/dd/yyyy) |
| PDF Url: |
http://www.ijciras.com/PublishedPaper/IJCIRAS1273.pdf |
Main Author Details
|
Name:
|
Md. Saifuzzaman Sazib |
| Institute: |
Department of Pharmacy, Jagannath University, Dhaka, Bangladesh. |
Co - Author Details
| Author Name |
Author Institute |
| Md. Islam Molla |
Department of Pharmacy, Jagannath University, Dhaka, Bangladesh. |
| Parimal Talukder |
Research and Development Division, Beacon Pharmaceuticals Ltd, Bangladesh |
| Mrityunjoy Biswas |
Dept. of Microbilogy And Immunology, Aichi Medical University |
Abstract
|
Research Area:
|
Pharmacy, Pharmacology & theraputics |
| KeyWord: |
Lyophilized injection, Bioavailability, Metastatic Melanoma, Dacarbazine |
| Abstract: |
To improve the bioavailability, stability, solubility and patient compliance lyophilized injection dosage form is extensively used in pharmaceutical industry. For better patient satisfaction particularly in bed ridden patients and for achieving maximum bioavailability the lyophilized injection has been considered as substitute to oral solid dosage forms. Lyophilization or freeze drying involves the elimination of water or other solvent from a frozen product by a process called sublimation followed by desorption. Freeze drying is a multistage process in which, quite obviously, each stage is critical. The key actors of this scenario are all recognized and should be under strict to complete a successful operation. Lyophilized products for parenteral use are known as Powders for injection or infusion. Dacarbazine is an alkylating agent administered as a first-line treatment for metastatic melanoma. As the stability of Dacarbazine in aqueous solution form was unstable it was formulated as Lyophilized product. The objective of the present study was to develop a stable lyophilized formulation of drug Dacarbazine for injection (200mg/vial). |
Citations
Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.
|
IEEE
|
Md. Saifuzzaman Sazib , Md. Islam Molla, Parimal Talukder , Mrityunjoy Biswas, "LYOPHILIZATION TECHNOLOGY FOR THE DESIGN, DEVELOPMENT, OPTIMIZATION AND EVALUATION OF AN ANTICANCER DRUG: DACARBAZINE", International Journal Of Creative and Innovative Research In All Studies,
vol. 2, no. 1, pp. 35-47, 2019.
|
|
MLA
|
Md. Saifuzzaman Sazib , Md. Islam Molla, Parimal Talukder , Mrityunjoy Biswas "LYOPHILIZATION TECHNOLOGY FOR THE DESIGN, DEVELOPMENT, OPTIMIZATION AND EVALUATION OF AN ANTICANCER DRUG: DACARBAZINE." International Journal Of Creative and Innovative Research In All Studies,
vol 2, no. 1, 2019, pp. 35-47.
|
|
APA
|
Md. Saifuzzaman Sazib , Md. Islam Molla, Parimal Talukder , Mrityunjoy Biswas (2019). LYOPHILIZATION TECHNOLOGY FOR THE DESIGN, DEVELOPMENT, OPTIMIZATION AND EVALUATION OF AN ANTICANCER DRUG: DACARBAZINE. International Journal Of Creative and Innovative Research In All Studies,
2(1), 35-47.
|
LYOPHILIZATION TECHNOLOGY FOR THE DESIGN, DEVELOPMENT, OPTIMIZATION AND EVALUATION OF AN ANTICANCER DRUG: DACARBAZINE
Number Of Downloads - 13
Last downloaded on 25/04/2023
