ManuScript Details
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Paper Id:
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IJCIRAS2037
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Title:
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NEOADJUVANT CHEMOTHERAPY IN ROUTINE PRACTICE FOR LOCALLY ADVANCED GASTRIC AND GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA
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| Published in: |
International Journal Of Creative and Innovative Research In All Studies |
| Publisher: |
IJCIRAS |
| ISSN: |
2581-5334 |
| Volume / Issue: |
Volume 8 Issue 8 |
| Pages: |
6
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| Published On: |
2/4/2026 8:34:50 PM (MM/dd/yyyy) |
| PDF Url: |
http://www.ijciras.com/PublishedPaper/IJCIRAS2037.pdf |
Main Author Details
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Name:
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Zoubida Behourah |
| Institute: |
Medical oncology department of university hospital of Oran |
Co - Author Details
| Author Name |
Author Institute |
| Ahlem Megaiz |
Medical oncology department of university hospital of Oran |
| Karima Hamidatou |
Medical oncology department of university hospital of Oran |
| Malika Lechar |
Medical oncology department of university hospital of Oran |
| Aicha Rabah |
Medical oncology department of university hospital of Oran |
| Abelkader Bousahba |
Medical oncology department of university hospital of Oran |
| Mohamed Yamouni |
Medical oncology department of university hospital of Oran |
| Amina Bensetti-Houari |
Medical oncology department of university hospital of Oran |
| Malika Ahed Messaoud |
Medical oncology department of university hospital of Oran |
| Soumeya Ghazli |
Medical oncology department of university hospital of Oran |
Abstract
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Research Area:
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Oncology |
| KeyWord: |
Gastric cancer, Gastroesophageal junction cancer, Neoadjuvant chemotherapy, Pathological complete response, Overall survival, Locally advanced cancer |
| Abstract: |
Background: Neoadjuvant chemotherapy has significantly improved outcomes in patients with locally advanced (LA) gastric cancer. This study aimed to evaluate the efficacy and safety of neoadjuvant chemotherapy in patients with LA gastric and gastroesophageal junction (GOJ) cancer in routine clinical practice.
Methods: We retrospectively analyzed 41 patients with LA gastric or GOJ adenocarcinoma who received neoadjuvant chemotherapy between January 2015 and December 2022. Clinical outcomes included treatment response, disease-free survival (DFS), overall survival (OS), and treatment-related toxicity.
Results: Median age was 55 years (range 22–69), and 73% were male. At diagnosis, 29.3% had stage II disease and 70.7% stage III. Neoadjuvant regimens included CF (61%), FOLFOX/XELOX (17%), and FLOT (22%). Thirty-nine patients (93%) completed chemotherapy. R0 resection was achieved in 61%, while 12% underwent exploratory procedures. Adjuvant chemotherapy was completed by 39% of patients.
Postoperative complications occurred in one patient (anastomotic leakage). Grade 3/4 adverse events included gastrointestinal toxicity (7.9%), leukopenia (12%), and anemia (7.9%). Disease control was observed in 68.3% of patients, tumor downstaging in 46.3%, and pathological complete response (pCR) in 17%. Five-year OS was 47% overall and 76% among patients who underwent surgical resection. No relapse occurred in patients with pCR. Median OS was 33 months, with a median follow-up of 68 months.
Conclusions: Neoadjuvant chemotherapy is effective and well-tolerated in LA gastric and GOJ adenocarcinoma. It facilitates curative surgery and improves long-term survival, particularly in patients achieving pCR.
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Citations
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IEEE
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Zoubida Behourah, Ahlem Megaiz, Karima Hamidatou, Malika Lechar, Aicha Rabah, Abelkader Bousahba, Mohamed Yamouni, Amina Bensetti-Houari, Malika Ahed Messaoud, Soumeya Ghazli, "NEOADJUVANT CHEMOTHERAPY IN ROUTINE PRACTICE FOR LOCALLY ADVANCED GASTRIC AND GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA", International Journal Of Creative and Innovative Research In All Studies,
vol. 8, no. 8, pp. 38-43, 2026.
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MLA
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Zoubida Behourah, Ahlem Megaiz, Karima Hamidatou, Malika Lechar, Aicha Rabah, Abelkader Bousahba, Mohamed Yamouni, Amina Bensetti-Houari, Malika Ahed Messaoud, Soumeya Ghazli "NEOADJUVANT CHEMOTHERAPY IN ROUTINE PRACTICE FOR LOCALLY ADVANCED GASTRIC AND GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA." International Journal Of Creative and Innovative Research In All Studies,
vol 8, no. 8, 2026, pp. 38-43.
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APA
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Zoubida Behourah, Ahlem Megaiz, Karima Hamidatou, Malika Lechar, Aicha Rabah, Abelkader Bousahba, Mohamed Yamouni, Amina Bensetti-Houari, Malika Ahed Messaoud, Soumeya Ghazli (2026). NEOADJUVANT CHEMOTHERAPY IN ROUTINE PRACTICE FOR LOCALLY ADVANCED GASTRIC AND GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA. International Journal Of Creative and Innovative Research In All Studies,
8(8), 38-43.
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NEOADJUVANT CHEMOTHERAPY IN ROUTINE PRACTICE FOR LOCALLY ADVANCED GASTRIC AND GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA
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