ManuScript Details
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Paper Id:
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IJCIRAS1115
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Title:
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EFFECT OF CHITOSAN AND DEXTROSE CROSSLINKING ON APPLE DERIVED CELLULOSE SCAFFOLD IN REGARD TO THEIR MECHANICAL PROPERTIES AND PROLIFERATION OF CELLS
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| Published in: |
International Journal Of Creative and Innovative Research In All Studies |
| Publisher: |
IJCIRAS |
| ISSN: |
2581-5334 |
| Volume / Issue: |
Volume 1 Issue 9 |
| Pages: |
10
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| Published On: |
2/14/2019 8:54:58 AM (MM/dd/yyyy) |
| PDF Url: |
http://www.ijciras.com/PublishedPaper/IJCIRAS1115.pdf |
Main Author Details
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Name:
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Anuska Aryal, Apar Wasti, Muna K.C., Pratima Poudel, Shiksha Niraula, Sonika Koirala |
| Institute: |
College of Biomedical Engineering and Applied Sciences |
Co - Author Details
| Author Name |
Author Institute |
| Mishal Pokharel |
College of Biomedical Engineering and Applied Sciences |
Abstract
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Research Area:
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Bio-engineering/ Technology |
| KeyWord: |
cellulose, scaffold, glutaraldehyde, HeLa cells, MTT assay, chitosan, dextrose |
| Abstract: |
Natural and synthetic scaffolds can be used as a substrate for the seeding and proliferation of cells. As cellulose and its derivatives have been successfully employed as biomaterials in various applications, the use of cellulose as a scaffold is viable. Easily produced, inexpensive apple derived cellulose scaffold, due to their natural origin and porosity, may prove to be a viable and even a better scaffold option compared to synthetic scaffolds. This research shows that the mechanical strength and the cell holding capacity of the apple derived cellulose scaffolds can be manipulated by crosslinking with glutaraldehyde, chitosan and dextrose. To compare the mechanical properties, swelling and solubility tests were performed along with the drug release capacity test; porosities of the scaffolds were compared and FTIR analysis was used to show the composition and crosslinking in the scaffolds. HeLa cells were used for the recellularization of the scaffolds and MTT assay was done to determine the cell proliferation in each type of scaffold. The scaffolds cross-linked with chitosan showed better swelling capacity and better cell proliferation compared to other cross-linked scaffolds. Glutaraldehyde cross-linked scaffolds had better mechanical strength, but the cell proliferation was comparatively low whereas the dextrose cross linking had no significant effect on mechanical properties but supported cell proliferation. |
Citations
Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.
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IEEE
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Anuska Aryal, Apar Wasti, Muna K.C., Pratima Poudel, Shiksha Niraula, Sonika Koirala, Mishal Pokharel, "EFFECT OF CHITOSAN AND DEXTROSE CROSSLINKING ON APPLE DERIVED CELLULOSE SCAFFOLD IN REGARD TO THEIR MECHANICAL PROPERTIES AND PROLIFERATION OF CELLS", International Journal Of Creative and Innovative Research In All Studies,
vol. 1, no. 9, pp. 63-72, 2019.
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MLA
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Anuska Aryal, Apar Wasti, Muna K.C., Pratima Poudel, Shiksha Niraula, Sonika Koirala, Mishal Pokharel "EFFECT OF CHITOSAN AND DEXTROSE CROSSLINKING ON APPLE DERIVED CELLULOSE SCAFFOLD IN REGARD TO THEIR MECHANICAL PROPERTIES AND PROLIFERATION OF CELLS." International Journal Of Creative and Innovative Research In All Studies,
vol 1, no. 9, 2019, pp. 63-72.
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APA
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Anuska Aryal, Apar Wasti, Muna K.C., Pratima Poudel, Shiksha Niraula, Sonika Koirala, Mishal Pokharel (2019). EFFECT OF CHITOSAN AND DEXTROSE CROSSLINKING ON APPLE DERIVED CELLULOSE SCAFFOLD IN REGARD TO THEIR MECHANICAL PROPERTIES AND PROLIFERATION OF CELLS. International Journal Of Creative and Innovative Research In All Studies,
1(9), 63-72.
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EFFECT OF CHITOSAN AND DEXTROSE CROSSLINKING ON APPLE DERIVED CELLULOSE SCAFFOLD IN REGARD TO THEIR MECHANICAL PROPERTIES AND PROLIFERATION OF CELLS
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