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Manuscript Details - IJCIRAS1739

ManuScript Details
Paper Id: IJCIRAS1739
Title: TASTE-NUMBNESS MASKED ODT OF RILUZOLE INTERNAL TERNARY SOLID DISPERSION
Published in: International Journal Of Creative and Innovative Research In All Studies
Publisher: IJCIRAS
ISSN: 2581-5334
Volume / Issue: Volume 3 Issue 11
Pages: 9
Published On: 5/2/2021 1:17:15 AM      (MM/dd/yyyy)
Main Author Details
Name: Dr. Mrs. Pradnya Palekar - Shanbhag
Institute: Oriental College of Pharmacy
Co - Author Details
Author Name Author Institute
Miss. Riya Chandra Oriental College of Pharmacy
Abstract
Research Area: Pharmacy, Pharmacology & theraputics
KeyWord: Riluzole, Syloid® 244 FP, PVP K30, internal ternary solid dispersion, orally disintegrating tablets, taste masking
Abstract: Riluzole, a glutamate antagonist used in management of neurodegenerative disorder Amyotrophic Lateral Sclerosis (ALS) has low aqueous solubility and leaves a sense of intense and persistent numbness in the mouth. The purpose of present study was to optimize orally disintegrated tablets (ODTs) of Riluzole by solid dispersion technology using hydrophilic polymer PVP K30 and surface modifying carrier Syloid® 244 FP for solubility enhancement and effective taste and numbness masking. Saturation solubility of prepared solid dispersion showed increase in solubility as compared to Riluzole in water, pH 1.2, 4, 6.8, 7.4 and 0.1 N HCl. Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and in vitro dissolution studies were done to characterize the solid dispersion system. Optimized taste masked ODTs showed 90% release of Riluzole in 45 mins comparable to that of the marketed film coated tablet. Thus, results conclusively demonstrated successful taste masking and rapid dissolution rate of the optimized ODT.
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IEEE
Dr. Mrs. Pradnya Palekar - Shanbhag, Miss. Riya Chandra, "Taste-Numbness Masked ODT Of Riluzole Internal Ternary Solid Dispersion", International Journal Of Creative and Innovative Research In All Studies, vol. 3, no. 11, pp. 33-41, 2021.
MLA Dr. Mrs. Pradnya Palekar - Shanbhag, Miss. Riya Chandra "Taste-Numbness Masked ODT Of Riluzole Internal Ternary Solid Dispersion." International Journal Of Creative and Innovative Research In All Studies, vol 3, no. 11, 2021, pp. 33-41.
APA Dr. Mrs. Pradnya Palekar - Shanbhag, Miss. Riya Chandra (2021). Taste-Numbness Masked ODT Of Riluzole Internal Ternary Solid Dispersion. International Journal Of Creative and Innovative Research In All Studies, 3(11), 33-41.
Taste-Numbness Masked ODT Of Riluzole Internal Ternary Solid Dispersion
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