ManuScript Details
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Paper Id:
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IJCIRAS1739
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Title:
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TASTE-NUMBNESS MASKED ODT OF RILUZOLE INTERNAL TERNARY SOLID DISPERSION
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| Published in: |
International Journal Of Creative and Innovative Research In All Studies |
| Publisher: |
IJCIRAS |
| ISSN: |
2581-5334 |
| Volume / Issue: |
Volume 3 Issue 11 |
| Pages: |
9
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| Published On: |
5/2/2021 1:17:15 AM (MM/dd/yyyy) |
| PDF Url: |
http://www.ijciras.com/PublishedPaper/IJCIRAS1739.pdf |
Main Author Details
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Name:
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Dr. Mrs. Pradnya Palekar - Shanbhag |
| Institute: |
Oriental College of Pharmacy |
Co - Author Details
| Author Name |
Author Institute |
| Miss. Riya Chandra |
Oriental College of Pharmacy |
Abstract
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Research Area:
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Pharmacy, Pharmacology & theraputics |
| KeyWord: |
Riluzole, Syloid® 244 FP, PVP K30, internal ternary solid dispersion, orally disintegrating tablets, taste masking |
| Abstract: |
Riluzole, a glutamate antagonist used in management of neurodegenerative disorder Amyotrophic Lateral Sclerosis (ALS) has low aqueous solubility and leaves a sense of intense and persistent numbness in the mouth. The purpose of present study was to optimize orally disintegrated tablets (ODTs) of Riluzole by solid dispersion technology using hydrophilic polymer PVP K30 and surface modifying carrier Syloid® 244 FP for solubility enhancement and effective taste and numbness masking. Saturation solubility of prepared solid dispersion showed increase in solubility as compared to Riluzole in water, pH 1.2, 4, 6.8, 7.4 and 0.1 N HCl. Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and in vitro dissolution studies were done to characterize the solid dispersion system. Optimized taste masked ODTs showed 90% release of Riluzole in 45 mins comparable to that of the marketed film coated tablet. Thus, results conclusively demonstrated successful taste masking and rapid dissolution rate of the optimized ODT. |
Citations
Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.
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IEEE
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Dr. Mrs. Pradnya Palekar - Shanbhag, Miss. Riya Chandra, "TASTE-NUMBNESS MASKED ODT OF RILUZOLE INTERNAL TERNARY SOLID DISPERSION", International Journal Of Creative and Innovative Research In All Studies,
vol. 3, no. 11, pp. 33-41, 2021.
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MLA
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Dr. Mrs. Pradnya Palekar - Shanbhag, Miss. Riya Chandra "TASTE-NUMBNESS MASKED ODT OF RILUZOLE INTERNAL TERNARY SOLID DISPERSION." International Journal Of Creative and Innovative Research In All Studies,
vol 3, no. 11, 2021, pp. 33-41.
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APA
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Dr. Mrs. Pradnya Palekar - Shanbhag, Miss. Riya Chandra (2021). TASTE-NUMBNESS MASKED ODT OF RILUZOLE INTERNAL TERNARY SOLID DISPERSION. International Journal Of Creative and Innovative Research In All Studies,
3(11), 33-41.
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TASTE-NUMBNESS MASKED ODT OF RILUZOLE INTERNAL TERNARY SOLID DISPERSION
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