ManuScript Details
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Paper Id:
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IJCIRAS1138
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Title:
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FORMULATION AND CHARACTERIZATION OF BETULINIC ACID LOADED POLYMERIC NANOPARTICLES FOR THE TREATMENT OF BREAST CANCER
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| Published in: |
International Journal Of Creative and Innovative Research In All Studies |
| Publisher: |
IJCIRAS |
| ISSN: |
2581-5334 |
| Volume / Issue: |
Volume 1 Issue 10 |
| Pages: |
13
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| Published On: |
3/25/2019 8:51:38 AM (MM/dd/yyyy) |
| PDF Url: |
http://www.ijciras.com/PublishedPaper/IJCIRAS1138.pdf |
Main Author Details
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Name:
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Meghraj Vivekanand Suryawanshi |
| Institute: |
SES'S R.C.Patel Institute of Pharmaceutical Education and Reserach, Shirpur |
Co - Author Details
| Author Name |
Author Institute |
| Dr. Hitendra S. Mahajan |
SES'S R.C.Patel Institute of Pharmaceutical Education and Reserach, Shirpur |
Abstract
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Research Area:
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Pharmacy, Pharmacology & theraputics |
| KeyWord: |
Betulinic acid, Conjugation, Lycoat RS 720, Bovine Serum Albumin, Anticancer |
| Abstract: |
The natural triterpenoid Betulinic acid has shown the anticancer properties. It showed poor aqueous solubility and high lipophilic nature. The aim of the study was to developed BA loaded Lycoat RS 720-BSA conjugated polymeric nanoparticles by the way of increasing solubility, bioavailability. Lycoat RS 720-BSA conjugate was prepared by Maillard Reaction. BA loaded nanoparticles was prepared by the solvent evaporation method. The detection of BA was determined by the HPLC at 210 nm. The nano-particles showed spherical shape with particle size 257 nm. The formulation showed the zeta potential -22.4 mV. The optimized batch showed the entrapment efficiency 88.32% and drug loading 6.84%. The drug content of optimized batch was found to be 78.10%. The in-vitro diffusion study show sustained release pattern and % diffusion was found to be 94.24% after 24 hrs. The in-vitro anticancer activity and accelerated stability study was performed. |
Citations
Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.
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IEEE
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Meghraj Vivekanand Suryawanshi, Dr. Hitendra S. Mahajan, "FORMULATION AND CHARACTERIZATION OF BETULINIC ACID LOADED POLYMERIC NANOPARTICLES FOR THE TREATMENT OF BREAST CANCER", International Journal Of Creative and Innovative Research In All Studies,
vol. 1, no. 10, pp. 15-27, 2019.
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MLA
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Meghraj Vivekanand Suryawanshi, Dr. Hitendra S. Mahajan "FORMULATION AND CHARACTERIZATION OF BETULINIC ACID LOADED POLYMERIC NANOPARTICLES FOR THE TREATMENT OF BREAST CANCER." International Journal Of Creative and Innovative Research In All Studies,
vol 1, no. 10, 2019, pp. 15-27.
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APA
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Meghraj Vivekanand Suryawanshi, Dr. Hitendra S. Mahajan (2019). FORMULATION AND CHARACTERIZATION OF BETULINIC ACID LOADED POLYMERIC NANOPARTICLES FOR THE TREATMENT OF BREAST CANCER. International Journal Of Creative and Innovative Research In All Studies,
1(10), 15-27.
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FORMULATION AND CHARACTERIZATION OF BETULINIC ACID LOADED POLYMERIC NANOPARTICLES FOR THE TREATMENT OF BREAST CANCER
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