ManuScript Details
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Paper Id:
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IJCIRAS1886
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Title:
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REVIEW OF FAST DISSOLVING TABLETS CONTAINING SOLID DISPERSION OF INDOMETHACIN
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| Published in: |
International Journal Of Creative and Innovative Research In All Studies |
| Publisher: |
IJCIRAS |
| ISSN: |
2581-5334 |
| Volume / Issue: |
Volume 4 Issue 12 |
| Pages: |
12
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| Published On: |
5/28/2022 6:06:27 AM (MM/dd/yyyy) |
| PDF Url: |
http://www.ijciras.com/PublishedPaper/IJCIRAS1886.pdf |
Main Author Details
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Name:
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Dr. Bharat .V. Jain |
| Institute: |
Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda-425107, Maharashtra, India |
Co - Author Details
| Author Name |
Author Institute |
| Mr. Tanveer .Y. Shaikh |
Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda-425107, Maharashtra, India |
| Mr. Siddhant .S. Tajane |
Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda-425107, Maharashtra, India |
| Dr. Sandip .R. Pawar |
Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda-425107, Maharashtra, India |
Abstract
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Research Area:
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Pharmacy, Pharmacology & theraputics |
| KeyWord: |
Fast Dissolving, Indomethacin, anti-inflammatory agent |
| Abstract: |
Indomethacin is class of non-steroidal anti- inflammatory drugs. It is act by inhibiting isoforms of cyclooxygenase 1 and 2. Indomethacin used in the treatment of moderate to severe rheumatoid arthritis including ankylosing spondylitis, osteoarthritis, tendinitis, bursitis and acute gouty arthritis etc. Indomethacin is practically insoluble in aqueous medium and highly permeable belong to BCS class II .Indomethacin shows very low and variable oral bioavailability due to poor dissolution in gastrointestinal fluid. This unwanted physical property of Indomethacin gives irritating side effects in gastrointestinal tract due to prolonged contact time with the mucosal layer of gastrointestinal tract. Solid dispersion methods are used to overcome this problem. Solid dispersion is commonly used technique to improve dissolution and bioavailability of poorly soluble drugs. The increase in dissolution rate for solid dispersion can be attributed to number of factors like particle porosity, particle size, wetting etc. Reduced particle size or reduced agglomeration, increased solubility or dissolution rate of poorly soluble drugs, Transferring drug from crystalline form to amorphous form, soluble complex formation in microenvironment, saturation of drug in microenvironment, Solubalisation of poorly soluble drug in presence of surfactant are some mechanisms of solid dispersion. From the past decades, there has been enhanced demand for more patients’ compliance dosage forms. Since the development cost of any new chemical drug is very high so for that reasons research and development department of many pharmaceutical companies focusing on the development of new drug delivery system for existing active ingredients.
Novel drug delivery systems aims for designing and development of dosage forms, convenient to manufactured and administered ,with reduced side effects, offering rapid release and enhanced bioavailability so as to achieve better patient compliance. In recent years, innovative drug delivery systems, like ‘Fast Dissolving Tablets’ have been developed and attracted the interest of many researchers.
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Citations
Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.
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IEEE
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Dr. Bharat .V. Jain, Mr. Tanveer .Y. Shaikh, Mr. Siddhant .S. Tajane , Dr. Sandip .R. Pawar, "REVIEW OF FAST DISSOLVING TABLETS CONTAINING SOLID DISPERSION OF INDOMETHACIN", International Journal Of Creative and Innovative Research In All Studies,
vol. 4, no. 12, pp. 70-81, 2022.
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MLA
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Dr. Bharat .V. Jain, Mr. Tanveer .Y. Shaikh, Mr. Siddhant .S. Tajane , Dr. Sandip .R. Pawar "REVIEW OF FAST DISSOLVING TABLETS CONTAINING SOLID DISPERSION OF INDOMETHACIN." International Journal Of Creative and Innovative Research In All Studies,
vol 4, no. 12, 2022, pp. 70-81.
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APA
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Dr. Bharat .V. Jain, Mr. Tanveer .Y. Shaikh, Mr. Siddhant .S. Tajane , Dr. Sandip .R. Pawar (2022). REVIEW OF FAST DISSOLVING TABLETS CONTAINING SOLID DISPERSION OF INDOMETHACIN. International Journal Of Creative and Innovative Research In All Studies,
4(12), 70-81.
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REVIEW OF FAST DISSOLVING TABLETS CONTAINING SOLID DISPERSION OF INDOMETHACIN
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